The European Society for Human Reproduction and Embryology (ESHRE) developed guidelines for diagnosing and managing premature menopause in 2016.
For diagnosing premature menopause, the following are required:
- Stoppage of periods for at least 4 months in women under 40
- Two blood tests at least 4 weeks apart showing increased levels (above 25 IU/L) of the hormone FSH
In patients with premature menopause, there is a higher chance of having problems with the adrenal and the thyroid glands. It is recommended to test for auto-antibodies against the thyroid and adrenal glands.
Because of the effects of oestrogen deficiency on bones, a specialised X-Ray to assess bone mass (DEXA) should be performed.