How is premature menopause diagnosed?

The European Society for Human Reproduction and Embryology (ESHRE) developed guidelines for diagnosing and managing premature menopause in 2016.

For diagnosing premature menopause, the following are required:

  1. Stoppage of periods for at least 4 months in women under 40
  2. Two blood tests at least 4 weeks apart showing increased levels (above 25 IU/L) of the hormone FSH

In patients with premature menopause, there is a higher chance of having problems with the adrenal and the thyroid glands. It is recommended to test for auto-antibodies against the thyroid and adrenal glands.

Because of the effects of oestrogen deficiency on bones, a specialised X-Ray to assess bone mass (DEXA) should be performed.